Neurodevelopmental risk factors for Autism скачать в хорошем качестве

Neurodevelopmental risk factors for Autism

Autism spectrum disorders (ASD) represent complex developmental syndromes of the central nervous system and most likely result from multiple etiologies with genetic and environmental contributions. Emerging evidence from epidemiologic, clinical, and preclinical studies indicates that environmental exposures, particularly those arising during the prenatal period and early childhood, may play important etiologic roles. We have evaluated relationships between prenatal environmental and early childhood factors and ASD in the Finnish Prenatal Study of Autism (FiPSA), a large seroepidemiologic investigation based on a national birth cohort. This study is characterized by availability of over 1 million archived maternal serum specimens that have been drawn and stored in virtually all pregnancies in Finland since 1983, comprehensive national psychiatric registries, and other population databases. The total sample of ASD cases in this birth cohort is over 4,000. Using these unique resources, we have demonstrated novel associations between autism and several early gestational maternal biomarkers, including an indicator of inflammation, thyroid autoantibody, and DDE, a metaboliteof the insecticide DDT. New findings on relationships between accelerated growth velocity of head circumference in the first year of life as an autism risk factor will be discussed. Moreover, novel data on other ASD risk factors to emerge from this cohort including interpregnancy interval and familial aggregation of neurodevelopmental disorders will be described. Finally, I will discuss new strategies aimed at improving our understanding of the specificity of risk factors for autism. The UC Davis MIND Institute is working to amplify the voices of the disability community and promote neurodiversity. This includes responding to concerns regarding the language and framing used to describe autism and other neurodevelopmental disabilities. We believe there is a benefit to maintaining access to historical presentations like those on our YouTube page, but recognize that the vocabulary used doesn’t always match the current preferred language. We appreciate the harmful impact of this outdated language, the discriminatory framework which fostered it, and the distress it may cause to some individuals. In an attempt to lessen this, we have changed the titles of presentations where appropriate. 0:00 Introduction 0:33 The envirome and neuropsychiatric development 2:36 Developmental precursors of neuropsychiatric disorders in epidemiologic studies 5:38 Child Health and Development Study (CHDS) Overview 16:41 Design advantages of the FIPS 26:40 Autoimmune disorders and ASD 41:32 Childhood head circumference and autism 49:33 Acknowledgements