Скачать с ютуб Gregor Anderluh - Pore forming toxins: from molecular mechanisms to nanosensing в хорошем качестве

Gregor Anderluh - Pore forming toxins: from molecular mechanisms to nanosensing

Pore-forming toxins are an important group of natural toxins. They act by forming pores of nm dimensions in cell membranes, which disrupts normal functioning of cells and can even lead to cell death. Many examples of pore forming toxins families exis t in all domains of life. Nep1-like proteins are important microbial effectors that disrupt plant membranes. They form small transient pores, which can be observed by a planar lipid bilayers approach using model membranes composed of sphingolipids purified from plants. The varying levels of conductances and noise indicated that pores differ in their architecture and size. We will also show how pore-forming toxins can be employed for sensing of macromolecules.