EvoFunPath Webinars Series - Penelope Kahn скачать в хорошем качестве

EvoFunPath Webinars Series - Penelope Kahn

Genetic mechanisms and fitness consequences of rapid evolution in severe and complex metal-contaminated environment A population can survive drastic environmental change through evolutionary rescue, where rare beneficial mutations allow some individuals to persist and rebuild the population. When multiple stressors interact, predicting this process becomes more difficult because their combined effects can be stronger (synergistic), weaker (antagonistic), or simply additive. In this study, Saccharomyces cerevisiae yeast was exposed to six metals and their pairwise combinations to identify which mutations enable evolutionary rescue and how they influence tolerance to other metals. Mutations affecting phosphate metabolism were often linked to broader cross tolerance. The metal pairs showed diverse interactions: manganese often created antagonistic effects, while copper tended to produce synergistic ones. Evolutionary rescue in antagonistic combinations generally produced mutations that improved fitness in each metal individually, whereas synergistic combinations favoured mutations specifically adapted to the combined stress. This work clarifies how organisms adapt to multiple simultaneous stressors, improving our ability to predict and manage populations threatened by environmental change.