CHAPTER 45 - Free Radicals and Antioxidant Nutrients: Damage, Protection, and Antioxidant Paradox скачать в хорошем качестве

CHAPTER 45 - Free Radicals and Antioxidant Nutrients: Damage, Protection, and Antioxidant Paradox

HARPER BIOCHEMISTRY CHAPTER 45 This examines free radicals, which are highly reactive molecules formed normally in the body, and their potential to cause significant cellular damage leading to diseases like cancer and atherosclerosis. It explores various sources of these radicals, including mitochondrial oxidation and activated macrophages, and details the body's protective mechanisms, such as antioxidant enzymes and nutrient-derived antioxidants. Crucially, this highlights an "antioxidant paradox," explaining that while some nutrients act as antioxidants, high concentrations, especially from supplements, can ironically become "pro-oxidants" and potentially increase mortality, suggesting that radicals also play a vital role in cellular signalling and programmed cell death.