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Most people think GLP-1 medications work because they “make you eat less.” That’s not the real mechanism. In this evidence-based lesson, Dr. Mohammed Paika — board-certified in Internal Medicine and Obesity Medicine — explains how GLP-1 medications actually work in the brain and body to regulate hunger, fullness, and food decision-making. GLP-1s don’t speed up metabolism. They don’t burn fat directly. And they don’t override biology. They restore disrupted brain–gut signaling that drives chronic hunger in obesity. When patients understand this, everything changes: • Why hunger feels quieter • Why portions feel smaller naturally • Why weight loss feels easier • Why this is treatment — not cheating This module breaks down the science simply so you can use GLP-1 therapy correctly, safely, and sustainably. YouTube Timestamps (3:44 Video) 0:00 — GLP-1s Don’t Work How You Think 0:18 — What GLP-1 Hormones Do in the Body 0:52 — Appetite vs Metabolism (Critical Difference) 1:28 — Brain–Gut Signaling Explained Simply 2:12 — Why Weight Loss Feels Easier on GLP-1s 2:55 — GLP-1s: What They Do vs Don’t Do 3:25 — Key Takeaway: Treatment, Not Cheating 👨⚕️ ABOUT DR. MOHAMMED K. PAIKA Board-Certified in Internal Medicine and Obesity Medicine Certified Personal Trainer & Nutrition Coach Helping people understand metabolism, hormones, and sustainable health through evidence-based medicine. 🧠 In This Video You’ll Learn ✔ How GLP-1 hormones regulate appetite ✔ Why obesity disrupts satiety signaling ✔ Appetite vs metabolism — critical difference ✔ Why GLP-1 weight loss feels easier ✔ What GLP-1 medications actually do (and don’t do) ✔ How to use GLP-1s for long-term success ⚖️ GLP-1s DO vs DON’T DO • Reduce appetite • Increase fullness • Reduce food noise • Improve blood sugar • Support calorie deficit DON’T • Burn fat directly • Speed metabolism • Replace nutrition • Replace exercise • Work without habits 👨⚕️ About Dr. Paika Dr. Mohammed K. Paika is double board-certified in Internal Medicine and Obesity Medicine and a Certified Personal Trainer & Nutrition Coach. He specializes in evidence-based obesity treatment, GLP-1 therapy, metabolic health, and sustainable fat loss. 📚 GLP-1 Course Playlist Start here → Module 1 Next → Expectations vs Reality 👍 Like 💬 Comment 📌 Share 🔔 Subscribe for more honest conversations about obesity, metabolism, hormones, and real-world health solutions DISCLAIMER: This video is for general information and educational purposes only and does NOT constitute the practice of medicine or other professional health services, including giving of a medical advice. NO doctor-patient relationship is formed. The use of this information and the materials provided in the video is at user’s own risk. The contents of the video are NOT intended to be a substitute for professional medical advice and are NOT intended to treat, diagnose, cure or prevent disease. You should NOT delay or disregard obtaining medical advice for any medical condition you have and you should first seek the assistance of your healthcare professional(s) for any such condition(s). You should NOT make any changes in your health regime, diet, medications, or supplements, before first consulting your physician or healthcare provider and before first obtaining a medical exam, diagnosis, and prescription/recommendation from your physician or healthcare provider. Mohammed Paika MD will not assume any liability for any direct or indirect losses or damages that may result from use of the information contained in this video, including but not limited to, economic loss, injury, illness, or death. Furthermore, all content in the video is subject to change without notice, so the content creator assumes no responsibility for the accuracy of information contained. Please review all information regarding any medical condition or use of medications and/or supplements with your physician or healthcare provider. The contents of this video are my personal opinion and do not represent that of my employer(s).