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Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life. ➡️ Download Here: https://www.jrennickemd.com/necessary... Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay and active for life. CHAPTERS: 00:00 - Start 00:23 - Introduction 01:02 - Importance 02:02 - LDL review 04:09 - Atherosclerosis Review 06:14 - History of LDL/lipid Research 09:14 - 3 types of supporting data 12:14 - Framingham Studies 13:31 - 4S Trial 14:34 - West of Scotland Study 15:24 - CARE Trial 16:37 - Heart Protection Study 17:03 - PROSPER Study 17:53 - PROVE IT - TIMI 22 Trial 19:03 - IDEAL Trial 20:12 - REVERSAL Trial 21:15 - ASTEROID Trial 22:18 - IMPROVE-IT 23:52 - DESCARTES Study 25:17 - OSLER 1/2 Trials 26:12 - ODYSSEY LONG-TERM Study 27:03 - GLAGOV Study 27:43 - LDL lowering and risk reduction meta analysis 28:41 - FOURIER Trial 29:12 - ODYSSEY OUTCOMES 29:52 - Further lowering LDL meta analysis 31:11 - CLEAR HARMONY Trial 32:23 - What is optimal LDL study 33:58 - Mendelian Randomization 36:22 - Putting it all together 38:43 - Summary REFERENCES Visit www.jrennickemd.com for a full list of references Disclaimer This video is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.