Genetic Toxicology & Carcinogenicity: Insights on Drug Safety, Mutation Risks, and Cancer Risk скачать в хорошем качестве

Genetic Toxicology & Carcinogenicity: Insights on Drug Safety, Mutation Risks, and Cancer Risk

Emery Pharma Speaker Series: Featuring Dr. Toufan Parman of Sangamo Therapeutics Emery Pharma was honored to welcome Dr. Toufan Parman, a renowned board-certified toxicologist and Senior Director of Non-Clinical Safety Evaluation at Sangamo Therapeutics, as a guest speaker at our recent Speaker Series event. With over 15 years of experience in toxicology, cell signaling, and cancer research, Dr. Parman has held key leadership positions, including Senior Director of Toxicology and Immunology at SRI International, where she led multiple departments and contributed extensively to advancing cancer and immunology research. Her academic journey began with a Ph.D. in Pharmaceutical Sciences and Toxicology from the University of Toronto, followed by post-doctoral research at prestigious institutions such as the NIH National Cancer Institute and Stanford University School of Medicine. During her presentation, titled *"Genetic Toxicology and Carcinogenicity: What Do We Need and When Do We Need It?"*, Dr. Parman provided an in-depth exploration of the concepts of genotoxicity and carcinogenicity. She explained that genotoxicity refers to the harmful impact of chemicals or physical agents on DNA, potentially causing mutations, while carcinogenicity pertains to the capacity of an agent to induce cancer, either by increasing mutation rates or accelerating tumor formation. Dr. Parman discussed the mechanisms behind these processes, which can occur through genotoxic or non-genotoxic pathways, such as cytotoxicity, cell proliferation, hormonal changes, or chromosomal damage. Dr. Parman further elaborated on the various assays used to assess genotoxicity and carcinogenicity, including the Ames test, micronucleus assays, and others. She emphasized the importance of conducting these assessments early in the drug development process to eliminate potentially harmful compounds and highlighted the regulatory timelines and recommendations for conducting such studies. Additionally, she touched on the distinction between small molecules and biologics, each requiring unique assessment approaches. Dr. Parman's insights provided a comprehensive look into the challenges and strategies involved in genetic toxicology and carcinogenicity assessments, emphasizing the importance of rigorous testing while striving to minimize the use of animal models. We are grateful for Dr. Parman's valuable contributions to our Speaker Series and look forward to continued collaboration with experts in the field. About Emery Pharma: Emery Pharma is deeply committed to advancing public health and exclusively focuses on projects that enhance the well-being of both individuals and the environment. As a comprehensive contract research laboratory, Emery Pharma provides extensive support across the entire spectrum of pharmaceutical development, covering small molecule drugs, biologics, biosimilars, gene therapy, botanicals, and more. Emery Pharma's array of premium services includes analytical and bioanalytical solutions, microbiology and cell biology services, drug and impurity characterization, and comprehensive R&D with cGMP/GLP support. The Emery Pharma team excels in customizing innovative solutions tailored to the unique requirements of each client. They seamlessly oversee the entire process, from initial drug discovery to thorough data analysis and insights generation. Their expertise allows them to tackle scientific challenges proactively, ensuring clients avoid unnecessary setbacks. Emery Pharma's accomplished chemists and biologists harness state-of-the-art technology, encompassing cutting-edge tools such as high-resolution mass spectrometry (Orbitrap), triple quad LC-MS/MS, GC-MS, preparative HPLC, and 400 MHz multinuclear NMR. For further details, please don't hesitate to reach out to Emery Pharma at [email protected] or explore their website at: https://emerypharma.com/