BAGIM Event: Chris Williams - Probing the Psychedelic Structure-Activity Space скачать в хорошем качестве

BAGIM Event: Chris Williams - Probing the Psychedelic Structure-Activity Space

Title: Probing the Psychedelic Structure-Activity Space Date: November 16, 2023 Speaker: Chris Williams, Director of Scientific Support, Chemical Computing Group Abstract: Psychedelic compounds are powerful substances that alter cognitive and sensory functions. Psilocybin (magic mushrooms), mescaline (peyote cactus) and Lysergic acid diethylamide (LSD) are tryptamine- and phenethylamine-based classical psychedelic compounds which primarily act as agonists and partial agonists against the serotonin 5-HT2A/2B receptors. The overall hallucinogenic properties of psychedelic compounds are highly sensitive to structural features and subject to cross-reactivity with monoaminergic receptors. To probe the SAR space of serotonergic hallucinogens, we have applied matched molecular pairs analysis in conjunction with conformational analysis to determine key pharmacophoric elements that contribute to agonist/partial agonist behavior. References: https://www.chemcomp.com/ Please follow BAGIM at https://www.meetup.com/boston-area-gr...   / bagimgroup     / 8129238