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Early-stage cutaneous squamous cell carcinoma: when choose Mohs over standard excision? Adults with early-stage cutaneous squamous cell carcinoma often present a surgical decision between Mohs micrographic surgery and standard excision. The core challenge is determining when Mohs meaningfully reduces recurrence risk and improves cosmetic outcomes versus when standard excision provides comparable effectiveness with fewer resource demands. This decision is complicated by tumor location, risk features, immunosuppression, recurrence status, and patient preferences. The discussion outlines a practical decision framework: defaulting to Mohs for low- to intermediate-risk tumors in cosmetically sensitive areas, while recognizing scenarios where standard excision or alternative strategies are appropriate. Emphasis is placed on balancing recurrence risk, tissue preservation, procedural burden, and system constraints. Clinical decisions should be guided by tumor risk, patient context, and qualitative triggers rather than routine preference. #Dermatology #CutaneousOncology #MohsSurgery #SkinCancer #SurgicalDecisionMaking