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Dr. Amber Molnar is a Nephrologist at St. Joseph’s Healthcare Hamilton. She is an Associate Professor with the Department of Medicine, Division of Nephrology at McMaster University and holds a cross appointment with the Department of Health Research Methods, Evidence and Impact. She received her MD at the University of Saskatchewan and completed Internal Medicine training at Western University. She then completed her Nephrology training followed by a two-year research fellowship and MSc in Epidemiology at the University of Ottawa. She is an Adjunct Scientist with ICES. In this role, she uses large, provincial healthcare databases to answer research questions pertinent to patients with kidney disease. Her research program focuses on improving outcomes for patients with advanced chronic kidney disease and on hemodialysis. She has an interest in pragmatic trials that make use of routinely collected data and streamlined, innovative approaches to patient consent and intervention delivery. Learning Objectives: Discuss the relationship between dialysate bicarbonate concentration and patient acid/base status. Describe the association between dialysate bicarbonate concentration and patient outcomes. Discuss the Dial-Bicarb trial