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The second installment of the Healthy Heart animated series expands on the idea that measures of remnant cholesterol may aid the early detection of CVD risk (especially in youth with unhealthy weight) and potentially curb the progression of Type-2 Diabetes. Obesity and unhealthy weight continues to be a global health concern, particularly in younger adults and youth. Youth with obesity often have a trajectory that increases their susceptibility to develop type 2 diabetes (T2D) and cardiovascular disease (CVD) in adulthood. Novel analysis of blood cholesterol measured in the fed-state (remnant cholesterol) in both youth with or without obesity suggests that it can be used as a clinical tool to identify early signs of CVD risk. A coordinated community-based approach to develop programs that can readily measure remnant cholesterol during the day is now needed in order to identify youth and young adults that may be at risk of early CVD.