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SCOG Virtual Lecture Series - Christoph Bock (CeMM, Vienna, AT)

Most diseases develop through the complex interplay of genetic and environmental influences, involving signaling pathways, metabolic changes, immune deregulation, and diverse cellular phenotypes. Our research is based on the hypothesis that the “epigenetic landscape” constitutes a highly informative intermediate layer of information processing that allows cells to maintain their regulatory state and cellular identity over time, while retaining the flexibility to respond swiftly to a broad range of perturbations. In our definition, the “epigenetic landscape” is not restricted to epigenetic marks such as DNA methylation and histone modifications. Rather, it reflects the full spectrum of transcription regulation by which cells translate various inputs into sustainable changes in their cell state. Notably, the epigenetic landscape not only reflects a cell’s current state, but also its developmental history (e.g., cell-of-origin in cancer) and its potential for future adaptation (e.g., plasticity in response to an immunological challenge). I will present our work within and beyond the Human Cell Atlas, dissecting epigenetic cell states in immunology and cancer; and I will present methods for causal, mechanistic analysis at scale (CROP-seq and KPNNs) and for ultra-high throughput transcriptome profiling in millions of single cells (scifi-RNA-seq). Funding: C.B. is supported by an ERC Consolidator Grant (n° 101001971) of the European Union. Biography: Christoph Bock is a Principal Investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor of [Bio]Medical Informatics at the Medical University of Vienna. His research combines experimental biology (high-throughput sequencing, epigenetics, CRISPR screening, synthetic biology) with computational methods (bioinformatics, machine learning, artificial intelligence) – for cancer, immunology, and precision medicine (https://www.bocklab.org &   / bocklab  . Before coming to Vienna, he was a postdoc at the Broad Institute of MIT and Harvard and a PhD student at the Max Planck Institute for Informatics. Christoph Bock is also scientific coordinator of the Biomedical Sequencing Facility of CeMM and MedUni Vienna, and he leads an EU Horizon 2020 project that contributes single-cell sequencing of organoids to the Human Cell Atlas. His research awards include the Otto Hahn Medal of the Max Planck Society, ERC Starting and Consolidator grants, the Overton Prize of the International Society for Computational Biology, and inclusion in the global list of “Highly Cited Researchers” by Clarivate Analytics (ISI Web of Science). He co-founded Aelian Biotechnology, a Vienna-based startup company that develops and applies single-cell methods for high-throughput biology and drug discovery. More info: https://www.singlecell.de; Twitter: @singlecellomics