Virtual Lab Tour at The Centre for Cancer Immunology скачать в хорошем качестве

Virtual Lab Tour at The Centre for Cancer Immunology

In this virtual lab tour, ABC funded lecturer Dr Charles Birts and his team at the University of Southampton will take you through the process of theoretically developing a novel antibody based therapy. Use the following timestamps to skip to specific parts of the process: 00:05 - Introducing the Centre for Cancer Immunology 00:37 - Discussing Immunotherapy and secondary breast cancer 02:10 - Explaining the steps that must be completed prior to a study commencing 02:43 - Handling and looking at patient samples in the microscope room 04:03 - Looking at breast cancer samples using a fluorescent microscope 05:00 - Engineering antibodies by modifying and amplifying DNA using PCR 06:09 - Growing breast cancer cells in the tissue culture room 07:10 - Looking at breast cancer cells down the microscope 07:27 - Purifying antibodies using the HPLC machine 08:42 - Testing the antibody using the Biacore 09:37 - The use of a Phagocytosis assay to test the antibody 10:11 - Watching a Macrophage destroying breast cancer cells tagged with the antibody 11:00 - Carrying out a Phagocytosis assay using a Flow cytometer 12:21 - Publishing and sharing work for peer review 12:42 - The clinical trials process and submitting results to the MHRA 16:21 - From the ABC team, thank you for your support About our work at The Centre for Cancer Immunology 2018 saw us complete our move into the new Centre for Cancer Immunology at University of Southampton. The building is the first of its kind in the UK and has been designed to bring together scientists, cancer doctors and clinical trials specialists to allow better collaboration and to deliver newly discovered science into patients for the first time. The relocation marks an exciting stage for our research programmes. Professor Crispin’s team are working on ways to redirect the body’s natural immune system to clear breast cancer cells that have spread from the site of origin. Their approach is to manufacture antibodies that have been artificially engineered to recognise cancerous cells in preference to surrounding healthy cells. Southampton has a long-pedigree in developing such therapeutic antibodies and the team will be working very closely with Professor Steven Beers who’s laboratory has all the expertise to determine the effectiveness of the new drug candidates in pre-clinical models. Recognising that major research advances requires a long-term vision we look forward to making further announcements relating to the development of this team under the leadership of Prof. Crispin and Prof. Beers at this state of the art facility. To learn more about the research we fund go to https://www.againstbreastcancer.org.uk/ To find out more about the Centre for Cancer Immunology go to https://www.southampton.ac.uk/youreit/