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Prostate: Men with an elevated serum level of prostate-specific antigen (PSA) or suspicious findings on digital rectal examination (DRE) are examined by transrectal ultrasound (TRUS). For histological confirmation and therapeutic plan- ning, ultrasound guided systematic biopsy of the prostate is performed. However, in a subgroup of patients with elevated PSA levels, no malignancy is detected by biopsy or up to four biopsies are performed before prostate cancer is detected. A negative biopsy therefore does not exclude prostate cancer. In consequence, unnecessary biopsies with an increase of complications are performed in healthy men. Real-time MR/US image fusion may enhance cancer detection rates of TRUS-guided biopsies and contributes to lesion characterization by state-of-the-art US techniques. The study presented here for the first time compares state-of-the art US techniques after contrast medium administration with MRI and histology as the standard of reference. Scrotum: Ultrasound is the imaging modality of choice for the examination of the scrotum. The propblem of tumour / haematoma misinterpretation can result in unnecessary orchiectomy. CEUS for the testis can be currently recom- mended for the differentiation between hypovascular and avascular lesions (benign). Learning objects: To investigate whether multiparametric magnetic resonance imaging (MRI) allows lesion localization in prostate can- cer in patients scheduled for MR/US fusion biopsy and whether the findings correlate with new ultrasound techniques Prostate lesions were classified on the basis of MRI and US (B-mode scan, power Doppler, elastography/TDI, CEUS) Targeted biopsies were performed in the MR/US fusionmode Indications for the use of CEUS in focal testicular lesions, secmental infartion, after trauma and abscess formation in severe epididymoorchitis. Satellite Symposia Ultrasound - ECR 2014