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Abstract: The room temperature liquid metals and their allied matters are a big class of newly emerging fundamental materials inherited with many fascinating properties and exciting application potentials which had never been anticipated in the old days. Particularly, their pretty easy transition between solid and liquid states endorse such materials with tremendous unconventional capabilities. Examples are rather diverse covering nearly all physical, chemical and engineering fields. From the thermal fluidic aspect, the emergence of the liquid metal electronic cooling at the early of this century opens revolutionary ways to break up the "thermal barrier" seriously challenging the worldwide high integration chips. In the electrical engineering category, the inventions of the liquid metal printed electronics and room temperature 3D metal printing in a little late time reshaped the rules of classical electronic and integrated circuit manufacturing, which are promoting such pervasively available electrical making tools into people's daily life. While for the health care of human being, the proposition of the liquid metal biomaterials at almost the same time brought about entirely new vision for tackling the major biomedical challenges. Along these endeavours, many scientific discoveries as achieved on liquid metals fundamentally stimulated the coming of a new era of soft robots: transformable liquid metal machines. All these exploded explorations open the huge space for the liquid metals to power next generation science, technology and industry. In this lecture, a brief glimpse and overview on recent liquid metal R&D activities over the world, especially in the author’s lab, will be given. Typical innovations on liquid metal materials, fundamental performances and scientific phenomena lying behind will be interpreted. Following that, a group of key technological and industrial applications will be illustrated which include but are not limited to: Liquid metal chip cooling and energy system, liquid metal printed electronics and 3D printing, liquid metal biomedical materials as well as liquid metal smart soft machines etc. Further, taking the industrial progress as examples, the foundation and practices of “The China Liquid Metal Valley” as well as efforts made there to mould a brand new industry of liquid metals will be introduced. Finally, some basic road map towards liquid metal material discovery will be summarized. Overall, the rise of the liquid metal science means many, not only academics but also society. It will be sure to help incubate pivotal progress of human civilization until finally change future industrial production ways and social life styles. As one classical proverb says, “one generation material represents one new era”. What we need to do in this day and age is just to try our best to investigate, utilize and advance such powerful and magic materials. Keywords: Liquid metal; Advanced cooling; Printed electronics and 3D printing; Biomaterial; Soft machines. Full Article: https://www.proceedings.iaamonline.or... Join us: https://www.iaamonline.org/