Treating Bipolar Depression: Beyond Symptom Control | Dan Iosifescu, MD, PhD скачать в хорошем качестве

Treating Bipolar Depression: Beyond Symptom Control | Dan Iosifescu, MD, PhD

Bipolar depression remains one of the hardest problems in psychiatry—not because we lack treatments, but because symptom control is often mistaken for recovery. Dan Iosifescu, MD, PhD, explains why many patients with bipolar depression—and especially those with mixed episodes—continue to struggle even when mood symptoms appear improved. Drawing on clinical experience and ongoing research, Dr. Iosifescu discusses: • Why symptom suppression does not necessarily lead to functional recovery • How sedation can reduce acute risk while preserving long-term disability • Why bipolar mixed episodes are uniquely dangerous and often misrecognized • The importance of distinguishing short-term response from durable treatment • How clinicians can think differently about non-response and treatment resistance The conversation also explores emerging, biologically grounded approaches to personalization, including combination strategies involving ketamine and established mood stabilizers, metabolic and mitochondrial interventions under investigation, and research into neuronal-derived exosomes and patient-specific brain organoids as potential tools for better treatment matching. This episode reframes what “working” should mean in bipolar depression—and why rethinking treatment goals may be essential for patients with the most complex presentations. CHAPTERS: 00:00 – Neuroplasticity, Energy, and Brain Healing 00:33 – Bipolar Depression: The Hardest Phase to Treat 02:39 – Functional & Cognitive Impairment in Bipolar Disorder 02:58 – A Composite Case: From High Functioning to Disability 05:29 – Rethinking Treatment: Ketamine, Lithium, and Glutamate Modulation 07:23 – Mixed Episodes & Suicide Risk 13:44 – The Future of Bipolar Treatment 16:18 – Metabolism, Mitochondria, and Novel Interventions 18:16 – Toward Biological Markers & Personalized Psychiatry ABOUT THE EXPERTS: Charles R. Marmar, MD: https://nyulangone.org/doctors/196250... Shu Professor of Psychiatry Director, Center for Precision Psychiatry NYU Grossman School of Medicine Dan Iosifescu, MD, PhD: https://nyulangone.org/doctors/183117... Director, Mood Disorders Clinical and Research Program Professor, Department of Psychiatry NYU Grossman School of Medicine Subscribe for more clinical innovations from NYU Langone Health. #InsightsonPsychiatry #BipolarDepression #Psychiatry #MentalHealth