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Michael Bogenschutz, MD, explains how psychedelic-assisted treatments may offer new options for patients with severe, treatment-refractory psychiatric conditions. He discusses why standard approaches often fall short for complex cases, how psychedelics like psilocybin and MDMA differ from conventional medications, and what careful screening and clinical structure make these treatments safe and effective. Drawing on randomized clinical trials and years of clinical experience, Dr. Bogenschutz describes how psychedelic treatments can produce durable symptom improvement in disorders such as alcohol use disorder and trauma-related conditions. He also explores unresolved scientific questions, including whether the psychedelic experience itself is necessary for therapeutic benefit. Michael Bogenschutz, MD, is Professor of Psychiatry and Director of the Center for Psychedelic Medicine at NYU Langone Health. CHAPTERS: 00:00 A Remarkable Case: Sustained Sobriety After Psilocybin Treatment 00:39 Introducing Dr. Michael Bogenschutz 01:04 Why Psychiatry Is Re-Examining Psychedelics 02:50 Safety, Screening, and Managing the Psychedelic Experience 03:45 Landmark Trial: Psilocybin for Alcohol Use Disorder 06:16 How Psychedelics Work: Neuroplasticity vs. Subjective Experience 08:53 Can Non-Psychedelic Analogs Deliver the Same Benefits? 11:47 MDMA, Fear Reduction, and Emotional Processing 13:44 Who Benefits Most? A Composite of Treatment-Refractory Patients 15:45 The Future of Psychedelic Psychiatry at NYU This episode is intended for psychiatrists, mental health clinicians, and others interested in complex and treatment-resistant psychiatric conditions. ABOUT THE EXPERTS: Charles R. Marmar, MD: https://nyulangone.org/doctors/196250... Shu Professor of Psychiatry Director, Center for Precision Psychiatry NYU Grossman School of Medicine Dr. Michael P. Bogenschutz: https://nyulangone.org/doctors/123518... Director, NYU Langone Center for Psychedelic Medicine ▶️ Watch Insights on Psychiatry on YouTube ▶️ Subscribe for more clinical innovations from NYU Langone Health