Pain: A Distributed Problem That Requires A Distributed Solution скачать в хорошем качестве

Pain: A Distributed Problem That Requires A Distributed Solution

with Robert Coghill, Ph.D. About: Understanding of central nervous system mechanisms supporting the experience of pain remains remarkably limited. This lack of understanding produces major challenges when seeking to better diagnose and treat chronic pain. A new framework - The Distributed Nociceptive System - emphasizes system-level aspects of nociceptive processing by incorporating population coding and distributed process. The Distributed Nociceptive System provides a conceptual structure for understanding the resiliency and complex spatial aspects of chronic pain. This framework supports that concept that pain is a distributed problem that requires a distributed solution and provides a clear rationale for the further development of multi-disciplinary treatments for chronic pain. Objectives: Define how nociceptive processing is distributed within the spinal cord and brain. Appraise how this distribution creates a highly resilient system. Using the conceptual framework of the distributed nociceptive system, evaluate how multidisciplinary therapy is potentially more effective than mono-therapy. Citations: 1.Coghill, R.C., The Distributed Nociceptive System: A Framework for Understanding Pain. Trends in Neuroscience. 2020;43(10):780-794. 2. Nahman-Averbuch, H., Schneider, V.J., 2nd, Chamberlin, L.A., Kroon Van Diest, A.M., Peugh, J.L., Lee, G.R., Radhakrishnan, R., Hershey, A.D., King, C.D., Coghill, R.C., Powers, S.W. Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents. Headache 2020;60(6):1165-1182. 3. Nahman-Averbuch, H., Schneider, V.J. II, Chamberlin, L.A., Kroon Van Diest, A.M., Peugh J.L., Lee, G.R., Radhakrishnan, R., Hershey, A.D., Powers, S.W., Coghill, R.C., King, C.D. Identification of neural and psychophysical predictors of headache reduction following cognitive behavioral therapy in adolescents with migraine. PAIN 2021;162(2):372-381. 4. Hoeppli ME, Nahman-Averbuch H, Hinkle WA, Leon E, Peugh J, Lopez-Sola M, King CD, Goldschneider KR, Coghill RC. Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation. Nat Commun. 2022;13(1):3569. Epub 2022/06/23. doi: 10.1038/s41467-022-31039-3. PubMed PMID: 35732637. 5. Adamczyk WM, Katra M, Szikszay TM, Peugh J, King CD, Luedtke K, Coghill RC. Spatial tuning in nociceptive processing is driven by attention. J Pain. 2023. Epub 2023/03/26. doi: 10.1016/j.jpain.2023.03.005. PubMed PMID: 36965648 Bio: Dr. Robert C. Coghill is the Director of the Pediatric Pain Research Center and a Professor in the Division of Behavioral Medicine and Clinical Psychology at Cincinnati Children's Hospital. Dr. Coghill earned his PhD from Virginia Commonwealth University and completed post-doctoral fellowships at the Universitè de Montrèal and the Montreal Neurological Institute, and the National Institutes of Health. He was the 2018 recipient of the Frederick W.L. Kerr medallion for his work in the basic science of pain. Dr. Coghill’s research interleaves data obtained with functional MRI of brain activity with subjective reports of pain and psychological state. He is highly interested in understanding how the nervous system evaluates and constructs an experience of sensory components of pain, including perceived intensity and location. Dr. Coghill also seeks to develop of better tools for the measurement of multiple dimensions of the pain experience. His laboratory is combining pain assessments, psychological profiles, and neuroimaging endpoints to develop strategies to better predict, diagnose, and treat pain. Together with a highly collaborative group of clinicians and scientists within the Pediatric Pain Research Center at Cincinnati Children’s Hospital, he is using these approaches to better understand multiple forms of pediatric chronic pain. Dr. Coghill serves as a Councilor for the International Association for the Study of Pain, Section Editor for imaging and measurement for PAIN, and on the National Advisory Council for Complementary and Integrative Health.