What are iModulons? скачать в хорошем качестве

What are iModulons?

QCB Seminar April 11, 2025. Bernhard Palsson,Departments of Bioengineering and Pediatrics, University of California, San Diego presented on iModulons. In the late 2000s, the cost of DNA sequencing dropped massively, leading to rapidly expanding data bases of microbial genome sequences and microbial transcriptomes. These data sets could be knowledge-enriched and decomposed into coherently functioning sets of genes using machine learning methods.A large compendia of high-quality RNAseq profiles can now be decomposed using Independent Component Analysis (ICA). ICA identifies independently modulated sets of genes, called iModulons. This talk shows the uses of iModulons for metabolic engineering and bioprocess development: including cross-species transfer of iModulons, media composition, expression of heterologous genes, and y-gene discovery.