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“Behind the hype and hashtags, millions of people are quietly reshaping their health with GLP-1s, but the stigma hasn’t caught up to the science.” Ozempic®, Mounjaro™, and other GLP-1 medications are changing how the world thinks about metabolism, weight, and longevity — but not without controversy. In this conversation, Dr. Bobby Parmar and Dr. Paul Maximus explore how these drugs went from diabetes treatments to cultural lightning rods. They dig into what science really says about GLP-1s, why moral bias still shapes how we talk about obesity, and what this shift means for the future of health and medicine. You’ll walk away with a deeper understanding of the biology behind appetite, the psychology of shame, and how longevity isn’t just about living longer — it’s about living better. WHAT YOU’LL LEARN • The physiological role of GLP-1 hormones in regulating hunger, satiety, and blood sugar • Why these treatments are helping patients with metabolic and cardiovascular disease — not just weight • The history of fat-shaming and why stigma still affects treatment access • How obesity is now understood as a chronic, relapsing condition — not a personal failure • What the research shows about long-term safety, muscle preservation, and sustained metabolic improvement TIMESTAMPS 0:00 Welcome to Off the Charts: The truth about GLP-1s and Ozempic 0:52 Why people hide their use of Ozempic and Mounjaro 2:52 Shame, willpower, and moral judgment in weight loss 4:55 Obesity as a disease — from circus cages to modern medicine 8:16 Fatphobia in healthcare and everyday life 9:13 Food noise, dopamine, and how our brains drive eating behavior 10:33 It’s not willpower — how biology shapes weight 13:55 The “cheating” narrative and natural vs pharmaceutical myths 15:31 The Gila monster story — how nature led to GLP-1 discovery 21:47 The rise of GLP-1 drugs and the billion-dollar shift 27:28 Why some doctors won’t prescribe Ozempic 32:30 Debunking “dangerous side effect” myths 37:27 Chronic disease, longevity, and why GLP-1s are for life 44:15 Muscle loss myths — what actually happens on Ozempic 48:38 Closing thoughts — send us your questions and hot takes EPISODE RESOURCES & REFERENCES To maintain transparency and support evidence-based discussion, every Off the Charts episode includes a companion page listing all primary research, clinical trials, and cultural references mentioned in the conversation. These references include publications from the New England Journal of Medicine, Physiological Reviews, the FDA, Obesity Canada, and more. TOP REFERENCES These sources were discussed or referenced in this episode and provide context on GLP-1 medications, obesity science, and cultural impact: • Holst JJ. (2007). The physiology of glucagon-like peptide-1 (GLP-1). Physiological Reviews. https://journals.physiology.org/doi/f... • Drucker DJ. (2018). Mechanisms of action and therapeutic application of GLP-1 and GIP. Cell Metabolism. https://pubmed.ncbi.nlm.nih.gov/29617... • Liraglutide and cardiovascular outcomes in type 2 diabetes. (2016). New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056... • U.S. Food and Drug Administration. (2024). FDA approves first treatment to reduce risk of serious heart problems in adults with obesity or overweight. https://www.fda.gov/news-events/press... • Obesity Canada. (2025). Recognizing and reducing weight bias in obesity management. https://obesitycanada.ca/wp-content/u... This resource page is for educational purposes only and does not constitute medical advice. CONNECT WITH GRAVITY HEALTH Website → https://www.gravityhealthclinics.com/ Book a Consult → https://gravityhealth.janeapp.com/ FOLLOW US Instagram → / gravityhealthclinics Dr. Bobby Parmar → / docparmar_nd Dr. Paul Maximus → / drmaximus Off the Charts is a podcast by Gravity Health, created for general informational and educational purposes only. It does not constitute the practice of medicine, nursing, or any other healthcare service, and should not be taken as medical advice. Listening to this podcast does not create a doctor–patient relationship. Listeners should always seek the guidance of qualified healthcare professionals regarding any medical condition or treatment. For more information about content use and disclaimers, please visit: https://www.gravityhealthclinics.com/... https://www.gravityhealthclinics.com/...