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Retatrutide’s startling Phase 3 results are finally here — and the numbers are unlike anything we’ve ever seen in obesity medicine. In this video, I break down the TRIUMPH-4 trial results in plain English, including the 28.7% weight loss, the 71-pound average drop, the record pain reduction, and the surprising discontinuation rates that are raising big questions about tolerability and access. Retatrutide isn’t just another GLP-1. It’s a triple agonist (GIP, GLP-1, and glucagon) that delivered the strongest weight-loss results ever recorded in a Phase 3 obesity trial — and it may reshape the entire future of obesity treatment. But these results come with a real warning: this medication is incredibly powerful, and some patients dropped out because they were losing weight too fast. We also dive into: How retatrutide compares to Zepbound, Mounjaro, Wegovy, and semaglutide The knee osteoarthritis pain results — up to 75.8% reduction Real-world weight-loss numbers including dropouts Side effects including nausea, vomiting, and dysesthesia FDA’s new accelerated pathway that could speed up retatrutide’s approval Why this will likely become Lilly’s most expensive obesity drug Retatrutide could change millions of lives — if patients can afford it and if insurers don’t block it behind impossible barriers. Lilly has a chance to be the hero here. The science is incredible. Now the question is: will people be able to get it? +++++++++++++++++++++++++++++++++++++++ Me Again Iphone GLP-1 App: https://apps.apple.com/us/app/meagain... Get your Hume BodyPod today and use our exclusive Downsized code for an extra 20% off on top of the sitewide sale—up to 50% total savings! 👉 Use our Code: THEDOWNSIZED Link to purchase: https://humehealth.com//discount/THED... To receive 20% off your Purchase of Biocare Protein Bars or Shakes, visit https://biocarenutrition.com/DOWNSIZED and enter the discount code DOWNSIZED To Purchase LARAINE’S BIOCARE FAVORITES https://biocarenutrition.com/products... and enter the discount code DOWNSIZED to receive an additional 20% AMAZON GLP-1 Companion Product Store: https://www.amazon.com/shop/downsized As an Amazon Associate, I earn from qualifying purchases. Start your weight loss journey today! We use Mochi Health: https://app.joinmochi.com/eligibility... Use Laraine’s code for $40 off: QIYGO8. DOWNSIZED LINKS Website: https://thedownsized.org Be our guest on The Downsized Dish: apply at https://thedownsized.org/downsized-dish/ Https://Thedownsized.Org/ Book The Downsized At Sea Cruise 2026: Https://Thedownsized.Org/Downsized-At... FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ +++++++++++++++++++++++++++++++++++++++ 00:00 Retatrutide Results So Strong, People Quit! PHASE 3 RESULTS 03:37 WHAT RETATRUTIDE IS — IN PLAIN ENGLISH 04:17 WHO WAS IN THE TRIUMPH-4 STUDY 05:37 WHAT THE TRIAL MEASURED 06:24 THE WEIGHT-LOSS RESULTS — THE STARTLING NUMBERS 07:32 KNEE PAIN IMPROVEMENT 08:28 THE REAL-WORLD NUMBERS WITH DROPOUTS INCLUDED 09:02 SIDE EFFECTS AND TOLERABILITY 09:59 HOW RETATRUTIDE COMPARES TO TODAY’S OPTIONS 10:26 FDA CHANGES MAY SPEED UP APPROVAL 11:19 PRICING AND ACCESS