Biochemistry Chapter 7 | Oxidative Stress: PPP, Respiratory Burst, Ethanol Metabolism скачать в хорошем качестве

Biochemistry Chapter 7 | Oxidative Stress: PPP, Respiratory Burst, Ethanol Metabolism

Try Med School Bootcamp for Free: https://bootcamp.com/med-school In this oxidative stress chapter, we break down the pentose phosphate pathway ie the HMP shunt and how it generates NADPH plus ribose 5 phosphate. We then connect NADPH to reduced glutathione, reactive oxygen species control, and major anabolic pathways that show up in board questions. You will learn: • Pentose phosphate pathway ie HMP shunt: makes NADPH and ribose 5 phosphate • NADPH role: keeps glutathione reduced to detox free radicals • G6PD deficiency: low NADPH leads to hemolytic anemia under oxidative stress • Oxidative burst: NADPH oxidase and myeloperoxidase create ROS to kill bacteria • CGD: defective NADPH oxidase, risk for catalase positive organisms • Ethanol metabolism: increased NADH drives lactic acidosis, ketoacidosis, hypoglycemia, and fatty liver ⏱️ Timestamps 00:02 Bootcamp intro 00:41 Chapter roadmap 00:59 PPP makes NADPH + ribose 5 P 02:57 G6PD is rate limiting 08:24 NADPH keeps glutathione reduced 11:15 G6PD deficiency: hemolysis risk 13:47 Oxidative burst overview 15:24 NADPH oxidase start 16:04 Myeloperoxidase makes HOCl 22:35 CGD and catalase positive bugs 28:40 Ethanol metabolism overview 30:16 ADH makes NADH 30:58 CYP2E1 uses NADPH, increases ROS 37:25 Disulfiram reaction 38:50 High NADH effects: lactic acidosis, ketoacidosis, hypoglycemia, fatty liver 50:25 Practice question: alcoholic ketoacidosis If it helps you out, give it a like, leave your questions in the comments, and subscribe for more Bootcamp videos. TikTok:   / medschoolbootcamp   INSTAGRAM:   / medschoolbootcamp   #medschoolbootcamp #medicine #Medical #MedStudent #MedicalStudent #MedSchool #MedicalSchool #Doctor #Resident #Hospital #MD #Med #Anatomy #Science #Whitecoat #WhiteCoatCeremony #MS1 #ms2 __________________________________________________________ oxidative stress biochemistry, pentose phosphate pathway, HMP shunt, NADPH biochemistry, G6PD deficiency, glutathione reductase, glutathione peroxidase, oxidative burst, respiratory burst, NADPH oxidase, chronic granulomatous disease, nitroblue tetrazolium test, catalase positive organisms, myeloperoxidase, hypochlorite bleach, superoxide dismutase, reactive oxygen species ROS, pseudomonas pyocyanin, ethanol metabolism, alcohol dehydrogenase, aldehyde dehydrogenase, CYP2E1, MEOS pathway, disulfiram reaction, metronidazole disulfiram like, acetaminophen NAPQI, alcoholic ketoacidosis, NADH NAD ratio, lactic acidosis alcohol, hypoglycemia alcohol, fatty liver alcohol, USMLE Step 1 biochemistry, medschool biochem review