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Monoamine Oxidase Inhibitors (MAOI) and ADHD

Main Chapters: 00:00 Intro – Monoamine Oxidase Inhibitors and ADHD 00:12 Take home message 00:52 What are Monoamines? 04:51 What are Monoamine Oxidase Inhibitors? (MAOI) 14:02 Types of MAOI Medications 21:20 MAOIs and Stimulants Monamine oxidase inhibitors (MAOI) prevent the breakdown of monoamine neurotransmitters, including dopamine, norepinephrine, and serotonin. From a basic science perspective, this makes them likely to be suitable agents for treating ADHD. Although MAOI were the first antidepressants, since the 1960's they've never made up more than 1% of the market share of medications used to treat depression. It's not that other medications are more effective, but MAOI can be dangerous if an individual contains tyramine rich foods (mostly fermented or aged foods like blue cheese, certain beers, and sausages). A handful of small studies (less than 100 patients total) have shown selegilene (Deprenyl) can be effective in treating ADHD. Whether this is through selegeline's MAOI, or because selegiline itself breaks down into L-methamphetaime and L-amphetamine, is unclear. ----- Free link to my Medium Article on Monoamine Oxidase Inhibitors and ADHD: https://medium.com/wise-well/most-foo... Follow   / dockruse   on Medium for hundreds of full length articles on this subject and more! Access to Full Medium articles requires paid membership. ----- Videos Mentioned: Glutamate and ADHD:    • Glutamate and ADHD   Aceytlcholine and ADHD:    • Acetylcholine and ADHD   Serotonin Syndrome: https://youtube.com/live/2j6kW5oL4U8 Rejection Sensitive Dysphoria and ADHD:    • Rejection Sensitive Dysphoria and ADHD   Methylene Blue and ADHD:    • Methylene Blue and ADHD   References: The Prescriber’s Guide to the MAOI Diet—Thinking Through Tyramine Troubles (2022) https://pmc.ncbi.nlm.nih.gov/articles... Placebo-Controlled Study Examining Effects of Selegiline in Children with Attention-Deficit/Hyperactivity Disorder (2006) https://www.researchgate.net/publicat... Selegiline in the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial (2003) https://pubmed.ncbi.nlm.nih.gov/12921... Selegiline in ADHD Adults: Plasma Monoamines and Monoamine Metabolites (1997) https://www.nature.com/articles/13805... A controlled trial of deprenyl in children with Tourette's syndrome and attention deficit hyperactivity disorder (1996) https://www.neurology.org/doi/10.1212... Full Chapter list: 00:00 Intro – Monoamine Oxidase Inhibitors and ADHD 00:12 Take home message 00:52 What are Monoamines? 02:24 Monoamine A and Monoamine B 03:23 Monoamine Acting Medications 04:51 What are Monoamine Oxidase Inhibitors? (MAOIs) 06:15 Dopamine, Norepinephrine, and Serotonin 08:09 Tyramine and MAOIs 11:43 Serotonin Syndrome and MAOIs 13:30 Other Potential Side Effects of MAOIs 14:02 Types of MAOI Medications 14:31 Selegiline (Deprenyl) 16:21 Selegiline and ADHD 18:14 MAOIs and Depression 19:51 MAOIs and Rejection Sensitive Dysphoria (RSD) 20:25 Methylene Blue 21:20 MAOIs and Stimulants 22:05 Outro ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuroatypical brains can optimize their functioning in our shared, and somewhat strange, world. ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of Politics related videos have an orange background. Dr. Kruse has posted videos in the "Videos", "Live", and "Shorts", sections of this channel. You're welcome to email him with topics you want discussed or people you think he should interview. drjohnkruse@gmail.com #health #mentalhealth #adhd #maoi #monoamineoxidaseinhibitor