In-Depth Review of Familial Dyslipidemias -Type I: Questions and Answers скачать в хорошем качестве

In-Depth Review of Familial Dyslipidemias -Type I: Questions and Answers

https://usmleqa.com/?p=27744 Question: What is Familial Dyslipidemias -Type I? Answer: Familial Dyslipidemias -Type I is also known as Hyperchylomicronemia.Question: How is Familial Dyslipidemias -Type I inherited? Answer: Familial Dyslipidemias -Type I is inherited as an Autosomal Recessive trait.Question: What is the pathogenesis of Familial Dyslipidemias -Type I? Answer: The pathogenesis of Familial Dyslipidemias -Type I is caused by a deficiency in lipoprotein lipase or apo CII.Question: What are the increased blood levels in Familial Dyslipidemias -Type I? Answer: The increased blood levels in Familial Dyslipidemias -Type I include Chylomicrons, TG, and cholesterol.Question: What are the clinical features of Familial Dyslipidemias -Type I? Answer: The clinical features of Familial Dyslipidemias -Type I include Pancreatitis, hepatosplenomegaly, and eruptive/pruritic xanthomas. It does not carry a risk for atherosclerosis.Question: What is the creamy layer in supernatant in Familial Dyslipidemias -Type I? Answer: The creamy layer in supernatant is a characteristic feature of Familial Dyslipidemias -Type I. Question: What is the role of lipoprotein lipase in Familial Dyslipidemias -Type I? Answer: Lipoprotein lipase is an enzyme that plays a critical role in the metabolism of lipids in the body. In Familial Dyslipidemias -Type I, there is a deficiency in this enzyme, leading to the build-up of chylomicrons and other lipids in the blood.Question: What is apo CII and its role in Familial Dyslipidemias -Type I? Answer: Apo CII is a protein that plays a crucial role in the metabolism of lipoproteins. In Familial Dyslipidemias -Type I, there is a deficiency in apo CII, which leads to the accumulation of chylomicrons and other lipids in the blood.Question: What is the significance of elevated levels of chylomicrons, TG, and cholesterol in Familial Dyslipidemias -Type I? Answer: Elevated levels of chylomicrons, TG, and cholesterol in Familial Dyslipidemias -Type I can lead to various clinical manifestations, such as pancreatitis, hepatosplenomegaly, and eruptive/pruritic xanthomas.Question: Can Familial Dyslipidemias -Type I lead to atherosclerosis? Answer: No, Familial Dyslipidemias -Type I does not carry a risk for atherosclerosis.Question: What is the creamy layer in supernatant in Familial Dyslipidemias -Type I? Answer: The creamy layer in supernatant is a characteristic feature of Familial Dyslipidemias -Type I and is observed when a sample of the patient's blood is centrifuged. The creamy layer is composed of chylomicrons and other lipids that have accumulated in the blood due to the deficiency in lipoprotein lipase or apo CII. Question: What is the treatment for Familial Dyslipidemias -Type I? Answer: Currently, there is no cure for Familial Dyslipidemias -Type I. The main goal of treatment is to reduce the risk of complications, such as pancreatitis, by controlling the levels of chylomicrons and other lipids in the blood. This may be achieved through lifestyle changes, such as a low-fat diet, and medications, such as fibrates and niacin.Question: How is Familial Dyslipidemias -Type I diagnosed? Answer: Familial Dyslipidemias -Type I is diagnosed based on the patient's clinical history, physical examination, and laboratory tests. Blood tests can reveal elevated levels of chylomicrons, TG, and cholesterol, while a diagnostic lipoprotein electrophoresis can confirm the presence of chylomicrons.Question: Can Familial Dyslipidemias -Type I be prevented? Answer: No, Familial Dyslipidemias -Type I cannot be prevented as it is an inherited condition. However, proper management and treatment can help to reduce the risk of complications and improve the patient's quality of life.Question: Are there any genetic tests available for Familial Dyslipidemias -Type I? Answer: Yes, genetic tests are available for Familial Dyslipidemias -Type I. These tests can help to confirm the diagnosis and determine the specific genetic mutations responsible for the condition. This itab