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Klinefelter Syndrome (47,XXY) is the most common chromosomal cause of male hypogonadism and infertility. But how do you recognize it clinically? And what’s the best management approach? In this high-yield genetics and endocrinology video, we explain everything you need to know about Klinefelter Syndrome—perfect for USMLE, MCCQE, PLAB, and NCLEX prep. What You’ll Learn in This Video: What is Klinefelter Syndrome? – Chromosomal abnormality (47,XXY karyotype) Pathophysiology – Seminiferous tubule dysgenesis → ↓ inhibin B → ↑ FSH, ↑ LH, ↓ testosterone → ↑ estrogen Key Clinical Features – Tall stature, gynecomastia, small firm testes, infertility, reduced facial/body hair Associated Risks – Increased risk of breast cancer, germ cell tumors, and learning difficulties Diagnosis – Karyotype analysis, hormone profile Treatment – Testosterone replacement therapy, fertility options (e.g., assisted reproduction) High-Yield Pearls – “Male with extra X chromosome → hypogonadism + gynecomastia” Support Our Work: Like this video? Subscribe and hit the to stay updated with free high-yield medical content from CanadaQBank. Follow CanadaQBank: Website: https://www.canadaqbank.com Facebook: / canadaqbank Twitter: / canadaqbank Free Demo: https://www.canadaqbank.com/register.... Hashtags: #KlinefelterSyndrome #47XXY #Genetics #Hypogonadism #Infertility #USMLE #MCCQE #PLAB #NCLEX #MedicalEducation #CanadaQBank CanadaQBank.com is an online test preparation service for the medical licensing exams of Australia (AMC CAT), Canada (MCCQE), Saudi Arabia (SMLE), United Kingdom (PLAB) and the United States (USMLE). In addition, CanadaQBank offers Android, iOS and Windows mobile applications which allow medical students and physicians to practice the questions and cases on their phones and tablets and study anywhere. Over 75,000 medical students and physicians from 190 countries have subscribed to CanadaQBank.com and studied with our QBanks to prepare for the AMC CAT, MCCQE, PLAB, SMLE and the USMLE. Read our 1000 verified Testimonials: https://canadaqbank.com/testimonials.php Subscribe to our YouTube channel and view over 500 Instructional Tutorial Videos about high yield topics tested on the AMC CAT (Australia), MCCQE (Canada), PLAB(United Kingdom), SMLE (Saudi Arabia), USMLE (United States). Our YouTube channel is here: / canadaqbank How to work as a Physician in Australia, Canada, Saudi Arabia, UK, USA: https://www.canadaqbank.com/physician...