Physiology Shorts: Is increased blood flow in hypoxia caused by brain tissue oxygen tension? скачать в хорошем качестве

Physiology Shorts: Is increased blood flow in hypoxia caused by brain tissue oxygen tension?

In this Physiology Shorts video, James Duffin (University of Toronto, Canada & Thornhill Medical, Toronto, Canada) talks about his latest study investigating whether blood flow increases during hypoxia and anaemia are caused by brain tissue oxygen tension. Read more in The Journal of Physiology: A mathematical model of cerebral blood flow control in anaemia and hypoxia James Duffin, Gregory M.T Hare & Joseph A. Fisher 598(4), pp. 717-730. https://physoc.onlinelibrary.wiley.co.... Transcript: Hello, my name is James Duffin. I am an emeritus professor in the departments of Physiology and Anaesthesiology at the University of Toronto. On retirement, some 15 years ago, I joined Thornhill Medical, as a senior scientist. During hypoxia and anaemia brain blood flow increases to offset the loss of oxygen supply. The mechanism underlying this response is not well understood, and in particular what the causative factor might be. Brain tissue oxygen tension seemed a good candidate, but a computer model simulation showed that brain tissue oxygen tension changes quite differently during hypoxia and anaemia. This finding suggests that it is not the causative factor. Thank you for taking the time to learn more about our study published in The Journal of Physiology. The full paper was published in Volume 598, Issue 4, and the computer simulation model is available in the supplemental information. Please contact me at j.duffin@utoronto.ca, if you have any questions.