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The Stigmines Trio BluesRock

This song is about the class of drugs that have the suffix - stigmines. Here three members namely physostigmine, neostigmine and rivastigmine are mentioned. They inhibit acetylcholinesterase in neuromuscular or synaptic junctions, thus making more acetylcholine (ACh) molecule available to act on target ion channels (i.e. Nicotinic Channel) and/or G-protein coupled receptors (muscarinic receptors). These agents help in improving cholinergic neurotransmission and as such can help in improving skeletal muscle movements and cognitive performance (if goes to the brain).