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In this episode of The Commune Podcast, Jeff welcomes back Dr. Gabrielle Lyon — physician, longevity expert, and author of The Forever Strong Playbook — to explore why skeletal muscle is the most overlooked organ in health and aging. They discuss the metabolic link between muscle and brain health, how to think about protein intake at any age, and why building strength safely over time matters more than just lifting heavier. Dr. Lyon also makes a compelling case for mindset as a core pillar of physical transformation. She shares practical ways to build mental toughness alongside muscle, from small daily friction exercises to doing hard things with your family. A grounded, actionable conversation for anyone ready to take their health seriously. ABOUT THE COMMUNE PODCAST Hosted by Jeff Krasno, the Commune podcast features thoughtful conversations for modern times. Not always comfortable but definitely needed, we explore both humanity and our human-ness. How can we live healthy, purpose-filled lives and be in service of something bigger? Guests include spiritual teachers, poets, scientists, philosophers, and activists for food sustainability, functional medicine, mental and physical health, and collective healing. LISTEN / SUBSCRIBE TO THE PODCAST Substack: https://jeffkrasno.substack.com/s/the... Apple Podcasts: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/1wdHmpa... Clips Channel: / @jeffkrasnoclips CONNECT WITH JEFF & COMMUNE Website: https://onecommune.com Instagram: @jeffkrasno and @onecommune Facebook: @jeffkrasno and @onecommune Substack: https://jeffkrasno.substack.com NEW TO COMMUNE? Hi, I’m Jeff Krasno. I’m the co-founder of Commune, host of the Commune Podcast, writer, dad, and seeker of community and connection. At Commune we explore health, spirituality, purpose, and culture with some of the world’s great teachers and thinkers. If you’d like to nourish your mind, body, and spirit with daily video lessons and practices that help you live well, explore Commune’s library of 100 wellness courses from the world’s top teachers with a 14-day FREE trial: 👉 https://www.onecommune.com/trycommune 00:00 Muscle as the organ of longevity 02:00 Why muscle matters beyond aesthetics 04:30 Insulin resistance and brain health 07:00 Alzheimer’s and metabolic dysfunction 09:15 Muscle contraction and myokines 12:00 Thinking faster through movement 15:40 Sarcopenia is not inevitable 18:30 GLP one drugs and muscle loss 22:10 Mindset as a training pillar 25:30 Capacity built through discomfort 28:45 Protein as the priority nutrient 31:00 Leucine and muscle signaling 34:00 Protein quality vs quantity 37:00 Muscle quality and intramuscular fat 39:30 Progressive over stimulus 42:00 Technique over heavier weight 44:30 Zone five and interval training 47:00 Sprint intervals and mental toughness 49:30 Active recovery and rest 52:00 Training as a family standard 54:30 Choosing the harder path early 56:00 Building stronger humans together