JAX In Motion | The Pera Lab: Mapping The Spectrum скачать в хорошем качестве

JAX In Motion | The Pera Lab: Mapping The Spectrum

By pairing stem cell technology with genetic diversity, JAX researchers uncover why identical mutations can lead to severe autism and other developmental brain disorders in some—and no symptoms in others. A new stem cell–based platform developed at The Jackson Laboratory (JAX) is shedding light on one of the biggest mysteries in genetics: why the same disease-causing mutation can affect people in dramatically different ways—from severe symptoms to no symptoms at all. Developed by JAX Professor Martin Pera, the platform uses induced pluripotent stem cells (iPSCs) from eight genetically distinct strains of mice. The breakthrough allows scientists to grow brain cells reliably from each strain, a major technical advance that opens the door to studying many other disease-linked genes in a more realistic and scalable way. Learn more: https://www.jax.org/news-and-insights...