Ask the Expert: Dr Fotios Sampaziotis & PhD student Teresa Brevini - Regenerating the Bile Ducts скачать в хорошем качестве

Ask the Expert: Dr Fotios Sampaziotis & PhD student Teresa Brevini - Regenerating the Bile Ducts

This is PSC Support 'Ask the Expert' live Q&A session was broadcast live on Facebook 02 October 2021 with 477 views. Regenerating the Bile Ducts: Game Changer or Daydream? Part 1 Presentation Part 2 Q&A (this video) Martine Walmsley (PSC Support) talks to Dr Fotios Sampaziotis & PhD student Teresa Brevini about their groundbreaking research into bioengineered bile ducts and what this could mean for PSC patients. Questions 00:38 Can you create artificial strictures in the lab so that drug can be tested directly on them? 03:28 How do the cells know where to go in the bile duct? 06:29 Is there a rejection issue with these organoids? 08:30 So these organoids are not artificial...because they are grown? 10:07 Could you take bile duct cells from someone with early PSC and store them for future use? 11:40 Why can't you simply replace the common bile duct with a tube made of artificial material? 13:34 Could you replace the injured bile duct with a collagen tube and allow the bile duct cells to grow in the body? 15:23 How quickly to the bile duct cells grow in the lab? 16:40 Are you looking for volunteers for clinical trials? 19:00 How long before this type of treatment could become available to patients? 22:03 Could we regenerate more than bile ducts? 23:46 Could norUrso (norUDCA) be a future treatment, given recent findings? 24:44 Do you have any views on what causes the most damage to cholangiocytes? 31:03 How long do the new cells take to grow and is this a determining factor in deciding if there is time to do this kind of treatment? 33:44 Do you see this as being a possibility to treat recurrent PSC? 37.48 Would a genetic test for PSC help with this treatment as it requires an early diagnosis? 45:28 Could you design a study where we take bile from someone with PSC one day and apply to bile duct in lab while monitoring diet to see how reabsorbed bile affects cholangiocytes based on diet. This would also take the immune system out of the picture. 47:56 Is there a point where too much scar tissue builds up, preventing the bioengineered cholangiocytes from sticking? Find PSC research at https://www.pscsupport.org.uk/cure Find Cambridge Stem Cell Institute at https://www.stemcells.cam.ac.uk/ Key information on PSC or healthcare professionals https://www.pscsupport.org.uk/HCPs