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A Cure for Obesity? Interview with Dr. Harith Rajagopalan Can obesity really be cured? In this exclusive interview filmed live from the ObesityWeek conference in Atlanta, Dr. Harith Rajagopalan, cardiologist, scientist, and CEO of Fractyl Health, joins Christopher Durham from The Downsized to talk about groundbreaking new therapies that target the root causes of obesity through the gut and pancreas. Dr. Rajagopalan explains how his company’s innovative treatments — including the Revita endoscopic procedure and the Rejuva platform — could one day help patients rewire the brain–gut connection, maintain weight loss without weekly GLP-1 injections, and potentially heal the disease of obesity. If you’ve ever wondered what comes after GLP-1s like Zepbound, Mounjaro, and Wegovy… this conversation offers a hopeful look at the future. 00:00 Welcome to the Downsized 00:47 Introduction to Harith Rajagopalan 01:19 Harith's Journey into Obesity Medicine 02:38 Personal Stories and Motivation 03:37 Challenges in Treating Obesity 04:49 The Role of Bariatric Surgery 07:34 Introducing Fractyl Health 08:36 Understanding the Brain-Gut Connection 13:31 Innovative Therapies for Obesity 18:08 Future Prospects and Clinical Trials 21:40 Comparing Bariatric Surgery and Tirzepatide 22:29 Insurance and the Cost of GLP-1 Medications 24:52 Therapy Number Two: RejuVa Platform 27:19 Mechanism of RejuVa and GLP-1 Hormones 29:29 Clinical Trials and Future Prospects 31:39 Hope and Future Innovations in Obesity Treatment 36:26 Conclusion and Final Thoughts