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How are electrochemical aptamer-based sensors being engineered to improve rapid diagnostics? In this lecture, recorded during the Know4Nano Workshop at BioSense Institute in November 2024, Dr. Claudio Parolo from the Barcelona Institute for Global Health (ISGlobal), Spain, presents recent advances in electrochemical aptamer-based sensors, from optical characterization to their implementation onto gold electrodes. The session highlights how these technologies can contribute to the future of rapid diagnostics, with strong potential for applications in global health. By improving the speed and efficiency of disease detection, aptamer-based sensing platforms are emerging as promising tools for more accessible and responsive diagnostic solutions. Know4Nano is a Horizon Europe project coordinated by BioSense Institute and focused on knowledge and skills transfer for the application of nanotechnology in biosensors for foodborne pathogens. The project strengthens research excellence and innovation capacity in areas such as nanomaterials, biosensors, microfluidics, food safety, project management, and technology transfer, with the goal of supporting the development of innovative, user-friendly diagnostic solutions along the farm-to-fork food chain. Follow Know4Nano here: Website: https://know4nano.com/ Facebook: https://www.facebook.com/p/Know4Nano-61567... Instagram: https://www.instagram.com/know4nanoproject/ LinkedIn: https://www.linkedin.com/company/know4nano/ X: https://x.com/know4nano #Know4Nano #BioSenseInstitute #HorizonEurope #AptamerSensors #ElectrochemicalSensors #RapidDiagnostics #GlobalHealth #Nanotechnology #Biosensors #Innovation #ResearchExcellence