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tVNS® has effects on seizures, mental state, cognitive and inflammation aspects in patients with epilepsy. tVNS® may help to increase the seizure threshold by increasing the parasympathetic activity through the stimulation in the brain stem, and reduce the number and severity of seizures. Regular electrical stimulation transmitted to the brain helps the development of neuroplasticity, cognitive and motor skills. It also helps to minimize the side effects of drugs by enabling the reduction of antiepileptic drugs used. By increasing the secretion of serotonin, it can increase mood and energy. Data on the relationship between inflammatory mediators and the production of immune cells and the recurrence of epileptic seizures are becoming more evident in the light of experimental and clinical studies. The positive results of anti-inflammatory treatments in epilepsy are being examined. Significant progress has been made in seizure control in inflammatory epilepsies such as encephalitis. In summary, tVNS is one of the primal treatment options in the treatment of epilepsy with its minimal side effects without any invasive operation and medication.