ESMO update: Advances in Upper GI Malignancies w/ Dr. Jun Gong | Tumor Board Ep. 44 скачать в хорошем качестве

ESMO update: Advances in Upper GI Malignancies w/ Dr. Jun Gong | Tumor Board Ep. 44

The FLOT regimen is the standard-of-care for upper gastroesophageal malignancies, but what if there were other drug combinations or perioperative strategies that could further improve outcomes? In Part II of our ESMO 2025 recap, medical oncologists Dr. Jun Gong and Dr. Jonathan Mizrahi cover emerging studies and treatments in gastroesophageal cancers. --- SYNPOSIS The discussion provides an overview of pivotal trials, including MATTERHORN, which demonstrated improved overall survival with durvalumab plus FLOT, and FORTITUDE-10, which highlights ongoing challenges in treatment efficacy with FGFR2b inhibitors. This episode also explores the role of lenvatinib-based combinations for esophageal squamous cell carcinoma and practical considerations for integrating checkpoint inhibitors into real-world clinical practice. --- TIMESTAMPS 00:00 - Introduction 01:23 - The MATTERHORN Study 03:24 - PD-L1 Status and Clinical Implications 07:09 - FORTITUDE-101 and 102 Studies: Discrepancies and Insights on FGFR2b Inhibition 11:15 - LEAP-014 and 015 Studies: The Role of Lenvatinib 14:57 - Conclusion and Final Thoughts --- RESOURCES Phase III MATTERHORN Study https://dailynews.ascopubs.org/do/mat... ESOPEC Phase III Trial https://pmc.ncbi.nlm.nih.gov/articles... FORTITUDE-101 Trial https://clinicaltrials.gov/study/NCT0... FORTITUDE-102 Trial https://clinicaltrials.gov/study/NCT0... LEAP-014 Phase III Study https://ascopubs.org/doi/10.1200/JCO.... LEAP-015 Study https://ascopubs.org/doi/10.1200/JCO-... --- BackTable Tumor Board is a multidisciplinary podcast for healthcare professionals that play an active role in cancer care. #ONC44 #oncology #esophagealcancer #gastroenterology