GABA & Glycine (Purves, Neuroscience, 6/e, Ch 6.5) скачать в хорошем качестве

GABA & Glycine (Purves, Neuroscience, 6/e, Ch 6.5)

I. Overview of Neurotransmitters Neurons communicate via chemical messengers called transmitters. Glutamate is the main excitatory neurotransmitter in the brain. GABA is the main inhibitory neurotransmitter in the human brain. Transmitters evoke responses by activating postsynaptic receptors. II. The Synthesis of GABA GABA is synthesized from glutamate by glutamic acid decarboxylase. This synthesis process requires pyridoxal phosphate as a cofactor. A vitamin B6 deficiency can reduce GABA and cause fatal seizures. High-affinity transporters called GATs remove GABA from synapses. III. Receptors for GABA GABAA receptors are ionotropic and function as chloride channels. Activation of GABAA receptors inhibits most postsynaptic cells. GABAB receptors are metabotropic and activate potassium channels. GABAB receptors can also block calcium channels for inhibition. IV. Properties of Glycine Glycine is an inhibitory neurotransmitter in the spinal cord. It is synthesized from serine by a mitochondrial enzyme. Glycine is removed from the synaptic cleft by plasma transporters. Glycine receptors are ligand-gated chloride channels. Strychnine blocks these receptors and causes toxic effects. V. Additional Resource Support See NourishED RFI's NotebookLM Resource Support Page. https://notebooklm.google.com/noteboo... VI. Source Purves, D., Augustine, G. J., Fitzpatrick, D., Hall, W. C., LaMantia, A.-S., Mooney, R. D., Platt, M. L., & White, L. E. (Eds.). (2018). Neuroscience (6th ed.). Oxford University Press. #Neuroscience #GABA #Glycine #Neurotransmitters #BrainScience #seizure #GAD #braindevelopment #benzodiazepines #alcohol ‪@neurochallenged‬ ‪@UrduBrainFacts‬ ‪@neuroscienceclasses7901‬