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📧 EM Note Newsletter https://forms.gle/8boToiKDXVE3V8U19 Signup to get free weekly PDF via email. PS: Please join our membership for more perks (members can request for specific PDF file by posting in the EM Note YouTube Membership section). Homepage: EMNote.org ■ 🚩Membership: https://tinyurl.com/joinemnote 🚩ACLS Lecture: https://tinyurl.com/emnoteacls The 2025 CPR Guidelines introduced by the American Heart Association (AHA) bring significant updates across adult, pediatric, and neonatal resuscitation, emphasizing standardization, ethical foundations, and evidence-based care. The guidelines include 760 recommendations, though only 1.4% are based on Level A evidence, reflecting the challenges in emergency care research. Key highlights include the introduction of a Universal Chain of Survival for all ages and settings, and a Newborn Chain of Care focusing on prenatal to postnatal care. Ethical principles, such as health equity and family presence during CPR, are emphasized to address systemic inequities and improve psychological outcomes for families. For Basic Life Support (BLS), a standardized protocol for foreign body airway obstruction (FBAO) involves 5 back blows + 5 abdominal thrusts for adults/children and 5 back blows + 5 chest thrusts for infants. The two-finger infant compression technique is eliminated, replaced by the heel of one hand or two-thumb encircling hands method. In Advanced Life Support (ALS), IV access is prioritized over IO access in adults. For refractory ventricular fibrillation, routine use of double sequential defibrillation is not recommended. Post-resuscitation care focuses on temperature control (≥36 hours) and blood pressure management (MAP ≥65 mmHg in adults). The guidelines stress system improvements, such as safety huddles and formalized debriefing for in-hospital readiness, and advocate for public access to naloxone alongside AEDs to address opioid emergencies. Finally, cognitive aids are recommended for healthcare professionals but not for lay rescuers, as they delay CPR initiation. For life-threatening hyperthermia, ice water immersion is the preferred method, targeting a cooling rate of ≥0.15°C per minute. These updates aim to improve outcomes, reduce disparities, and enhance global consistency in resuscitation practices.