PNAS 2021 Cozzarelli Prize Winner for Class IV: Biomedical Sciences скачать в хорошем качестве

PNAS 2021 Cozzarelli Prize Winner for Class IV: Biomedical Sciences

Lipopeptide-mediated bacterial interaction enables cooperative predator defense Shuaibing Zhang, Ruchira Mukherji, Somak Chowdhury, Lisa Reimer, and Pierre Stallforth Communities of microbes can cooperate to defend against predators. In this study, the authors found that two unrelated bacterial strains, Pseudomonas and Paenibacillus, each susceptible to predation by amoebae, exchanged natural products to defeat predators when the strains were grown together. When exposed to predatory amoebae, one strain produced a molecule called syringafactin, which induced the other strain to produce enzymes called peptidases. The peptidases broke down syringafactin into fragments that proved toxic to the amoebae. This study shows how microbes work together to guard against predators and suggests that microbial interactions may be a source of novel and potent bioactive compounds. Read the award-winning research article: https://www.pnas.org/cgi/doi/10.1073/... For more information about the Proceedings of the National Academy of Sciences, visit www.pnas.org.