CMap Analysis - Candidate Therapeutic Discovery Based on Disease-Drug Transcriptomic Similarity скачать в хорошем качестве

CMap Analysis - Candidate Therapeutic Discovery Based on Disease-Drug Transcriptomic Similarity

The method of drug discovery based on drug-drug similarity has two principal limitations: (1) one needs to have at least one known drug or compound to query the database and (2) the discovered new compounds may mostly belong to the same class as the queried drug or compound. Therefore, in order to find potential therapeutics for disease that has no known therapeutic, one has to explore the “connectivity” between the queried disease and all known or investigational drugs. In the following example, using psoriasis, an immune-mediated, inflammatory, and hyperproliferative disease of the skin and joints, we will present a step-by-step approach to find novel candidate therapeutics for psoriasis.