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Recurrent pregnancy loss is a frustrating experience and complicated diagnosis. There are many potential causes and a lot that is still unknown or "unexplained" In this interview, which took place on Instagram in December 2020, Dr. Winifred Mak gives and overview of the causes, diagnostic workup, and treatments of RPL. Dr. Mak, MD, PhD is an Associate Professor at UT Health Science San Antonio as well as Associate Professor at Dell Medical School, UT Austin and a board-certified Reproductive Endocrinologist with a special interest in RPL. She is the director of the Early Pregnancy Loss program at UT Health Austin. Her research focuses on uncovering new causes for unexplained pregnancy loss. To learn more from Dr. Mak, visit https://www.miscarriagemd.com/ Recurrent Pregnancy Loss Association (RPLA) is a 501c3 nonprofit organization funding research into RPL and providing support and education to families who have been impacted by pregnancy loss. Subscribe, follow us, and join our mailing list at https://rplassociation.org/ Chapters: 0:00 Introduction 6:16 Definition of "recurrent pregnancy loss" 8:40 When to get evaluated? 10:32 The standard RPL workup 15:02 Chances of success after RPL 18:44 When everything comes back "normal" 25:09 Is IVF with PGT-A a solution? 30:07 What about reproductive immunology? 36:53 Does progesterone supplementation help? 43:00 I've tried it all. Now what? 49:03 Benefits of testing miscarriage tissue 52:17 Thank you and close