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Thought Leader: Dr. Sarah Burke is an analyst with the ProDugo Group, supporting the Department of Defense Scientific Test and Analysis Techniques Center of Excellence. She specializes in experimental design, quality engineering, statistical modeling, and complex test planning for defense acquisition programs. Dr. Burke holds a BS in Mathematics from the University of Vermont and an MS in Statistics and PhD in Industrial Engineering from Arizona State University. Her work spans response surface methods, statistical engineering, multi criteria decision making, and advanced analysis for highly constrained systems. She is also an active contributor to the American Statistical Association and the American Society for Quality. Topic Overview: This fireside chat explores lessons learned from designing and analyzing experiments for a fast jet life support system. Dr. Burke discusses how constrained factor spaces, human breathing simulations, and laboratory limitations shape test design decisions. She explains the shift from categorical breathing profiles to continuous factors, introduces the use of D optimal designs for constrained regions, and highlights the importance of early planning with subject matter experts. The session also covers functional data analysis for time dependent responses, screening designs under operational constraints, and practical strategies for working with engineers and acquisition programs to ensure successful test execution.