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Abstract #01.05.05 — THE ASSOCIATIONS BETWEEN MENTAL HEALTH AND HIV/PrEP ADHERENCE SELF-EFFICACY IN JAIL Author(s) :: Holliday R; Spaulding A; Yussuf A Author(s) Affiliation(s) :: Morehouse School of Medicine (RH); Emory Rollins School of Public Health (AS); Spelman College (AY) Approximately 1.2 million people in the United States are living with HIV, with an estimated 13% unaware of their diagnosis, and Black and Hispanic communities as well as incarcerated populations experience disproportionately higher HIV prevalence. Individuals in jail face elevated HIV risk due to factors such as unprotected sex, injection drug use, and barriers to prevention and care, including stigma, medical mistrust, transportation challenges, and mental health conditions. Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV when taken consistently; however, adherence remains a challenge, particularly among justice-involved populations. Prior research indicates that anxiety and depression are more prevalent among individuals living with or at risk for HIV compared to the general population, yet limited research has examined how these mental health outcomes relate to HIV/PrEP adherence self-efficacy in jail settings. This study examines the association between depression, anxiety, and HIV/PrEP adherence self-efficacy among individuals incarcerated in jail using baseline data from the Emory and Morehouse School of Medicine Substance Use and HIV Action for Re-entry and Engagement (SHARE) Project, which connects individuals in Fulton County Jail to substance use treatment and HIV prevention and care through peer navigation. Participants completed measures of depression (PHQ-9), anxiety (GAD-7), and HIV/PrEP adherence self-efficacy; among the 82 participants enrolled to date, 84% identify as Black/African American, 92% as cisgender men, and 28% are living with HIV. Linear regression analyses will assess whether depression and anxiety predict HIV/PrEP adherence self-efficacy, with findings informing a larger implementation trial to increase PrEP uptake in Metro Atlanta jails. Grant Support :: This study is funded by the National Institute of Drug Abuse grant #1R61DA062365. This research was supported in part by the RCMI Student Research Training Program. To stay up-to-date with more health equity news, follow: #XULACon #1JGCollabs