Episode 11 - Progesterone Primed Ovarian Stimulation Episode скачать в хорошем качестве

Episode 11 - Progesterone Primed Ovarian Stimulation Episode

Progestin-primed ovarian stimulation (PPOS) is increasingly utilized in assisted reproductive technology (ART) for ovarian stimulation. Various progestins have been employed with comparable success. Studies indicate that the ovarian response to stimulation with PPOS is similar to that with gonadotrophin-releasing hormone (GnRH) analogues. Differences in the duration of stimulation or gonadotrophin consumption are minor and clinically insignificant. PPOS offers the advantages of oral administration and lower medication costs compared to GnRH analogues, making it a more cost-effective option for fertility preservation and planned freeze-all cycles. However, for fresh embryo transfer, PPOS may be less cost-effective depending on the local costs associated with the additional initial frozen embryo transfer cycle. Oocytes retrieved from PPOS cycles exhibit similar developmental potential, including comparable blastocyst euploidy rates. Frozen embryo transfer outcomes from PPOS and GnRH analogue cycles appear similar in terms of ongoing pregnancy/live birth rates and obstetric and perinatal outcomes. While some studies have reported lower cumulative live birth rates with PPOS, these studies have methodological limitations, such as arbitrary definitions of cumulative live birth rate. PPOS has been used successfully in all patient types, except for those with progesterone receptor-positive breast cancer, and appears to be a patient-friendly and cost-effective option if fresh embryo transfer is not planned.