Ibogaine Synthesis & How It Might Solve the Opioid Crisis / Treat Addiction | Psychedelic Science скачать в хорошем качестве

Ibogaine Synthesis & How It Might Solve the Opioid Crisis / Treat Addiction | Psychedelic Science

This video explains biochemistry, organic synthesis and physiological effects - including pre-clinical research on mice/ rats - of ibogaine, ibogamine and other related molecules which might prove useful as the need for effective therapies against substance use disorder and other addiction disorders increase. If you like the video, consider commenting, sharing it with a fellow nerd, and subscribing to the channel so you do not miss future videos! https://total-synthesis.com/organic-c... 🧑‍🎓➡️ Free organic chemistry practice problems   / totalsynthesis   🚀 Thanks to all channel supporters!!!   / totalsynthesis_official   👉 Follow me on Instagram to follow updates on other random chemistry research and interesting news! https://total-synthesis.com 00:00 Ibogaine, a magic bullet against addiction? 01:08 Iboga bark: The root of ibogaine & friends 03:11 Effects in the body and similarities to other psychedelics or substances 06:26 Ibogaine's efficacy in heroin addiction 07:21 Safety risks (cardiotoxicity, neurotoxicity) 08:57 How to master any scientific topic- easy and free! 10:18 18-MC (18-methoxycoronaridine): A safer ibogaine? 13:12 TBG (tabernanthalog): An even safer and easier-to-synthesize ibogaine 15:00 How do we test hallucinations, heroin/ alcohol dependency or depression? 21:21 Outlook on MindCure, ibogaine treatment clinics and federal/state priorities 22:52 Synthesis of ibogaine and ibogamine (organic chemistry) 28:38 Synthesis of 18-MC (organic chemistry) This video was sponsored by Brilliant. Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. Key references: DARK Classics in Chemical Neuroscience: Ibogaine | ACS Chem. Neurosci. 2018, 9, 2475 Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice | J. Food. Bioact. 2018, 3, 111 A systematic literature review of clinical trials and therapeutic applications of ibogaine | Journal of Substance Abuse Treatment 2022, 138, 108717 Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes| Front. Pharmacol., Sec. Neuropharmacology 2018, 9: 00529 The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation | Molecules 2015, 20, 2208 18-Methoxycoronaridine (18-MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action | Annals of New York Academy of Sciences 2000, 914, 369 A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature 2021, 589, 474 The Total Synthesis of (±)-Ibogamine and of (±)-Epiibogamine | JACS 1965, 87, 2073 Total synthesis of ibogaine, epiibogaine and their analogues | Tetrahedron 2012, 68, 7155 Gram-Scale Total Synthesis of (±)-Ibogamine | Org Lett 2023, 25, 4567 Chemical Synthesis and Biological Evaluation of 18-Methoxycoronaridine (18-MC) as a Potential Anti-addictive Agent | Current Med Chem CNS Agents 2001, 1, 113 Some recommended books on organic synthesis: Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)