Modeling Alzheimer's Disease in Genetically Modified C Elegan Strains Khushi Yadav скачать в хорошем качестве

Modeling Alzheimer's Disease in Genetically Modified C Elegan Strains Khushi Yadav

Alzheimer's disease (AD) is a neurodegenerative condition that affects over 50 million worldwide. Its main symptoms include loss of mobility and memory. While current treatments seek to relieve the symptoms, there is no known cause yet to stop the disease's progression. There is indication that multiple factors work to cause the disease, since some types (Early-Onset AD) are more impacted by genetics, while others (Late-Onset AD) worsen with age and other unknown factors. Amyloid beta aggregation has been observed to cause toxicity in neurons and is highly common in AD patients, and thus its role in the propagation of AD has been studied extensively. Here, we will discuss the observation of amyloid beta aggregation's effects on the muscle cells and neurons of C. elegans, taking in data from both our lab work and past studies. We predict a loss of short term associative memory (STAM) and long term associative memory (LTAM), as well as decreased mobility. Researchers: Khushi Yadav, Frances Jing, Simran Tawari, Tanvi Sri Sai Penugonda, Arnav Rao, Sripradha Manikantan ASDRP Research Advisor: Carly Truong