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Menopause and ADHD

Main Chapters: 00:00 Intro - Menopause and ADHD 00:20 Take home message 01:48 What is Menopause? 07:37 Potential Effects of Menopause on Brain Functions 09:53 Studies on Menopause and ADHD-Like Symptoms 20:26 Conclusion As of the end of 2024 there are no studies examining women with ADHD before, during, and after their perimenopausal years. This reflects how medicine in general has relatively ignored women, ignored the importance of menopause, and not recognized the importance of ADHD in women. Nevertheless, research indicates that many women experience concentration, attention, memory and mood regulation issues during perimenopause (when estrogen and progesterone doses are fluctuating) and in menopause (where levels of these two hormones are minimal). Robust concentrations of estrogen receptors in the prefrontal cortex, involved in executive functions, are thought to be how menopause may impact brain function. The impairment of many women during perimenopause appears to be as severe as those who have full blown ADHD. Preliminary evidence suggests that diminished estrogen levels result in less dopamine and more glutamate in the prefrontal cortex, and that treatments including hormonal replacement therapy, atomoxetine, and lisdexamfetamine can help reduce ADHD symptoms. ----- Free link to my Medium article on Menopause and ADHD: https://medium.com/wise-well/the-brai... Follow   / dockruse   on Medium for hundreds of full length articles on this subject and more! Access to other Medium articles requires paid membership. ----- References: Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women (2011) https://pmc.ncbi.nlm.nih.gov/articles... New onset executive function difficulties at menopause: a possible role for lisdexamfetamine (2015) https://link.springer.com/article/10.... Cognitive Problems in Perimenopause: A Review of Recent Evidence (2023) https://link.springer.com/article/10.... Full Chapter list: 00:00 Intro - Menopause and ADHD 00:20 Take home message 01:48 What is Menopause? 02:28 Symptoms in Perimenopause and Post-Menopause 04:29 Potential Medical Interventions for Menopausal Symptoms 06:21 Difficulties in Researching the Effects of Menopause 07:37 Potential Effects of Menopause on Brain Functions 08:46 Impact of Hormones on the Brain 09:53 Studies on Menopause and ADHD-Like Symptoms 10:53 Evaluating ADHD Symptoms with the BADDS Scale 12:22 Study on Atomoxetine and Menopause 14:45 Study on Vyvanse and Menopause 18:02 Study on Vyvanse and Menopause Using Brain Imaging 19:54 Study on Hormone Replacement Therapy and Menopause 20:26 Conclusion 22:41 Outro ------------------------- Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuroatypical brains can optimize their functioning in our shared, and somewhat strange, world. ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of Politics related videos have an orange background. Dr. Kruse has posted videos in the "Videos", "Live", and "Shorts", sections of this channel. You're welcome to email him with topics you want discussed or people you think he should interview. drjohnkruse@gmail.com #health #mentalhealth #adhd #menopause