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We are reviewing the mood disorders and evidence-based practice guidelines that psychiatric–mental health nurse practitioners (PMHNPs) use in treating clients who have these disorders. Mood disorders are the most prevalent psychiatric illnesses, often treated in primary care settings due to somatic symptoms. Distinguishing between normal sadness and pathological levels of sadness is crucial for PMHNPs evaluating depression. Major depression is a brain-based illness requiring treatment; it can lead to serious health issues if left untreated. Sadness exists on a continuum, with mild depression sometimes being a healthy response to stress, while pathological sadness has specific criteria. Major Depressive Disorder (MDD) is characterized by persistent mood disturbances and can occur with or without a known trigger. The etiology of depression includes psychological theories (e.g., Object Loss Theory and Aggression-Turned-Inward Theory), focusing on early developmental issues and loss experiences. Book for ANCC exam prep https://a.co/d/5QUECdY PMHNP exam prep https://a.co/d/155Tvkr FNP Certification https://a.co/d/3yFHl23