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In this This Is Why with Dr. Busti pharmacology, Dr. Busti makes this pharmacology 101 review of loop diuretics easy by breaking down the science and clinical application of diuretic pharmacology —a cornerstone drug class for fluid overload, heart failure management, and edema treatment. Drawing on Dr. Busti's 30 years of experience as a nurse, pharmacist, physician, and educator, he explains renal pharmacology and the mechanism of action at the loop of Henle, their pharmacokinetic differences, and why understanding their mechanisms helps prevent common pitfalls such as side effects of diuretics (e.g., electrolyte disturbances), diuretic resistance, and hemodynamic instability. This session translates complex renal physiology into clear, clinically relevant knowledge—connecting the why behind loop diuretics’ powerful therapeutic effects and potential risks in both inpatient and outpatient care. The goals = pharmacology made relevant & pharmacology made easy. 👉 Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/p... Get more with a free membership at https://www.thisiswhy.health/ Access free downloads from our videos Access deep dive content from Dr. Busti Organize content via playlists & collections Join live Q&A Receive member newsletters Coupons & discounts for exam prep resources Chapter Table of Contents 00:00:00 – Intro & Why Loop Diuretics Matter 00:04:29 – Drug Lineup: Furosemide, Bumetanide, Torsemide (+ Ethacrynic Acid) 00:05:03 – Indications: Edema, Heart Failure, Fluid Overload 00:10:19 – Mechanism of action: Rapid Diuresis 00:13:08 – Renal Pharmacology: Getting Drug to Site of Action 00:14:56 – Nephron Tour → Thick Ascending Limb Focus 00:39:22 – PK & Dosing: PO vs IV, Potency, Ceiling Doses, Conversions of Loop Diuretics 00:54:15 – Electrolytes: K⁺/Mg²⁺/Ca²⁺ Loss, QT Risk, Contraction Alkalosis 00:59:09 – Side Effects of Diuretics & Drug Interactions: Ototoxicity, NSAIDs, Digoxin, Lithium 01:05:33 – Monitoring: Vitals, Daily Weights, BMP/CMP, Renal Function 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures on diuretics, antihypertensives, antibiotics, and more! #loopdiuretics #furosemide #pharmacology #pharmacologymadeeasy #nursingpharmacology Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.