The Many Lives of mRNA - Stirling Churchman, PhD скачать в хорошем качестве

The Many Lives of mRNA - Stirling Churchman, PhD

In this presentation, Dr. Stirling Churchman of Harvard Medical School describes the dynamic life cycle of RNA. She reveals how RNA molecules move through the cell, how long they linger in each compartment, and what this tells us about gene regulation and cellular health. Using metabolic labeling, biochemical fractionation, and computational modeling, Dr. Churchman’s team uncovers surprising insights into RNA kinetics, including the discovery of widespread nuclear degradation in specific gene sets. Learn how RNA flow rates vary across the genome, how machine learning helps identify key regulatory features, and why understanding RNA dynamics is crucial for decoding gene expression and disease mechanisms. 00:00 Introduction 01:12 Monitoring 'RNA flow' with metabolic labeling 07:18 Kinetic modeling of RNA flow 09:59 Nuclear degradation models 12:23 Variability of genome-wide RNA flow rates 16:08 Machine learning insights 20:43 Questions and answers Visit the Churchman Lab at Harvard Medical School: https://churchman.med.harvard.edu/ #rna #science #technology The presentation was part of the Open Science Day that was hosted at the Washington University in St. Louis and supported by the National Human Genome Research Institute (NHGRI) and The Jackson Laboratory.