Black rice alleviates colorectal cancer development through tryptophan metabolism and AHR pathway скачать в хорошем качестве

Black rice alleviates colorectal cancer development through tryptophan metabolism and AHR pathway

Ling Wang, Yi-Xuan Tu, Lu Chen, Ke-Chun Yu, Hong-Kai Wang, Shu-Qiao Yang, Yuan Zhang, Shuai-Jie Zhang, Shuo Song, Hong-Li Xu, Zhu-Cheng Yin, Ming-Qian Feng, Jun-Qiu Yue, Xiang-Hong Huang, Tang Tang, Shao-Zhong Wei, Xin-Jun Liang, Zhen-Xia Chen. 2024. Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway. iMeta 2: e165. https://doi.org/10.1002/imt2.165 Consumption of dietary fiber and anthocyanin has been linked to a lower incidence of colorectal cancer (CRC). This study scrutinizes the potential antitumorigenic attributes of a black rice diet (BRD), abundantly rich in dietary fiber and anthocyanin. Our results demonstrate notable antitumorigenic effects in mice on BRD, indicated by a reduction in both the size and number of intestinal tumors and a consequent extension in life span, compared to control diet-fed counterparts. Furthermore, fecal transplants from BRD-fed mice to germ-free mice led to a decrease in colonic cell proliferation, coupled with maintained integrity of the intestinal barrier. The BRD was associated with significant shifts in gut microbiota composition, specifically an augmentation in probiotic strains Bacteroides uniformis and Lactobacillus. Noteworthy changes in gut metabolites were also documented, including the upregulation of indole-3-lactic acid and indole. These metabolites have been identified to stimulate the intestinal aryl hydrocarbon receptor pathway, inhibiting CRC cell proliferation and colorectal tumorigenesis. In summary, these findings propose that a BRD may modulate the progression of intestinal tumors by fostering protective gut microbiota and metabolite profiles. The study accentuates the potential health advantages of whole-grain foods, emphasizing the potential utility of black rice in promoting health.