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On May 20, 2025, ICAP presented the Grand Rounds — Insights from Successful Marburg Virus Outbreak Response. Marburg virus disease (MVD) is a severe and often fatal hemorrhagic fever that is clinically similar to the Ebola virus disease. In fall 2024, Rwanda experienced the third-largest recorded MVD outbreak, with 66 reported cases and 15 deaths, the majority of which were among healthcare workers. In response, Rwanda’s Ministry of Health launched a comprehensive national program that included widespread public health awareness campaigns, promotion of hygiene practices, strict monitoring of transmissions, isolation of potential cases, effective treatment protocols for confirmed cases, and the distribution of investigational vaccines and therapeutics. The Ministry of Health declared the outbreak over by December 2024. Although there are currently no licensed vaccines or treatments for MVD, several candidate vaccines are in development, and some have entered clinical trials. Experts from the Rwanda Biomedical Centre and the International AIDS Vaccine Initiative (IAVI) shared experiences and lessons learned from managing the MVD outbreak in Rwanda and the development of a candidate vaccine.